Reviewed the current structure of problems of global security in the development of civilization in the XXI century. The role of humanitarian factors in solving these problems and set the priorities of the world community in the coming period. It is shown that in the first place, they should be aimed at preventing a new world war. The prerequisite for this is ensuring that the geopolitical and military balance between East and West, as well as further arms reduction and demilitarization of the economy. The following priorities are ensuring the compatibility with the biosphere of man and nature in the process of development of civilization, overcoming the systemic crisis of modern culture, and anthropological crisis, signs of which are becoming more prominent.